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KMID : 1011620080240010046
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Korean Journal of Food and Cookey Science
2008 Volume.24 No. 1 p.46 ~ p.51
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Antioxidative and Antimutagenic Activity of Ethanol Extracts from Cuscutae Semen
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Jeon Yeon-Hee
Kim Mi-Hyun
Kim Mee-Ra
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Abstract
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In this study, the antioxidant and antimutagenic activities of Cuscutae semen ethanol extract were evaluated. Antioxidant activity was measured by the 1,1 -diphenyl-2-picrylhydrazy 1 (DPPH) method and the Ames test was employed to determine the inhibition effect on mutagenicity in Salmonella typhimurium TA100. The extract showed significant free radical-scavenging activity towards the DPPH radical, and at a concentration of 400 ppm, its free radical-scavenging activity was similar to that of BHT. The IC50 value of the extract was 89 ppm, indicating good antioxidant capacity. Moreover, at 5 mg/mL, the extract presented inhibitions of approximately 98.0% and 49.2% on mutagenicity induced by 4-nitroquinoline 1-oxide and sodium azide, respectively. The total polyphenols and flavonoid contents of the extract were 20.1 mg/g and 1.9 mg/g, respectively. Therefore, this study indicates that the ethanolic extract of Cuscutae semen has excellent antioxidative and antimutagenic potential.
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KEYWORD
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Cuscutae semen, antioxidant activity, antimutagenicity, Ames test, DPPH
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